2025 Men’s Final Four Odds, Picks, & Predictions

After a gruelling regular season and a thrilling first four rounds of the NCAA Tournament, March Madness 2025 has culminated in a blockbuster Final Four as the Florida Gators, Auburn Tigers, Houston Cougars, and Duke Blue Devils compete to become National Champions.

To the dismay of some, but thrill of others, this year’s tournament has been all chalk, with this becoming just the second time ever since the field expanded to 68 teams in 1985 that we’ve seen all four one-seeds reach the Final Four. The last time this occurred was in 2008.

With the best of the best set to square off, the only way these high-stakes matchups could get any more intense is by throwing down a bet on the action.

Below we’ve included where you can score the best odds on the 2025 Final Four, as well as our expert picks on how we see each matchup playing out, as well as our prediction to win the National Championship.

If you’re looking to place a bet on the 2025 Final Four, be sure to check out the best March Madness betting sites in Canada so you can score a big win on this year’s college basketball finale.

Don’t wait, get some skin in on the game today and make this year’s NCAA Tournament one for the history books.

Florida vs. Auburn

Best Odds on Florida to Win: BET99 (-150)
Best Odds on Auburn to Win: bet365 (+135)

Kicking off the Final Four with the first matchup between top-ranked teams, the Florida Gators will take on the Auburn Tigers. With the Gators hungry to snap their jaws on their third National Championship in school history, the Tigers are out for blood as they hope to claim their first-ever National Championship.

While both teams have looked strong throughout their March Madness runs, look for this game to go in favour of Florida.

Having been more battle-tested in this year’s tournament, the Gators have proven themselves to have the mental fortitude and ambition to fight till the final buzzer, a quality lost on many teams. This trait has been on full display this season, including their recent comeback victory against Texas Tech in the Elite Eight.

Auburn has looked solid throughout their Final Four run, but certainly hasn’t faced any team close to the talent level of the Gators.

Look for Florida to rely heavily on the standout scoring ability of junior Walter Clayton Jr. as he continues to be a walking bucket in the biggest moments of the game, then utilizing its sensational size to command the glass and dictate the pace of the game.

Expect to see Florida emerge with the victory in a low-scoring affair, as Auburn has finished all four of its tournament matchups with under 159.5 points scored.

Prediction: Florida Moneyline + Under 159.5 Points

Houston vs. Duke

Best Odds on Houston to Win: bet365 (+210)
Best Odds on Duke to Win: Sports Interaction (-250)

In another clash between a team with a prolific history within March Madness against a school looking for its first National Championship, the Duke Blue Devils will take on the Houston Cougars.

Pitting the top defensive team in the nation against one of the best offences in the country has set the stage for a matchup that’s sure to be chock-full of fireworks on the hardwood.

While the Cougars have continued to improve year-after-year, look for their National Title hopes to once again get dispelled as they fall to the Blue Devils in the Final Four.

The Houston defence, as good as it has been, is still at risk of a collapse as they take on a star-studded Duke team. Rostering top NBA prospects Cooper Flagg and Kon Knueppel, the Blue Devils duo has had no trouble getting buckets on their opponents throughout the season.

During the 2025 NCAA Tournament the Cougars have shown several instances of vulnerability, almost choking away a lead late to Gonzaga in the Round of 32, as well as a nail-biter against Purdue in the Sweet Sixteen. Meanwhile, Duke has been steamrolling opponents throughout March Madness, holding an average margin of victory of 23.5 points through the first four rounds.

Bank on the Blue Devils to once again cruise to victory, forcing the Cougars to play their brand of basketball as the over quickly hits in this matchup, with Duke ultimately reigning supreme over Houston.

Prediction: Duke Moneyline + Over 136.5 Points

NCAA Tournament Outright Winner Prediction

Based on our predictions found above, we envision a National Championship Game between the Florida Gators and the Duke Blue Devils.

These two squads have been by far the best teams in the NCAA this season, and it will all culminate in a must-see showdown with college basketball immortality on the line.

Both sides of this matchup have legitimate championship aspirations and the talent to back it up, but we don’t think the outcome of this matchup needs to be overthought, ride with the Blue Devils. Having sat atop, or within the Top 5 of the AP Polls throughout the regular season, the Blue Devils have lived up to the hype in every way possible this season.

With the superior on-court talent, as well as a rich history of success at the highest level, look for the favourites to go the distance as the Blue Devils secure their sixth National Championship and net you a healthy boost to your bankroll in the process.

2025 NCAA Champion Prediction: Duke Blue Devils