Wrapping up Week 17 of the 2024 NFL season with a spectacular battle between two skilled NFC squads, the Detroit Lions will look to continue their domination over their conference against the San Francisco 49ers.
Bet on Lions vs. 49ers
DET -3.5
SF +3.5
In a rematch of last year’s NFC Championship Game, there’s sure to be no shortage of bad blood on display between these two teams. The only way the action of the Lions vs. 49ers could get any better is by placing a bet on the latest Monday Night Football odds.
Below we’ve compiled the latest Lions vs 49ers odds, winning NFL betting trends, as well as our expert predictions on the outcome of Monday’s duel.
Score your next big win using our Lions vs. 49ers betting preview featured below and send your bankroll skyrocketing with our top moneymaking picks and predictions.
| Lions Moneyline Odds | -200 |
| 49ers Moneyline Odds | +165 |
| Spread odds | Lions -3.5 (-110), 49ers +3.5 (-110) |
| Over/Under | Over 50.5 points (-110), Under 50.5 points (-110) |
| Time/Date | Dec 30, 8:15 p.m. ET |
| TV | Broadcast: TSN/DAZN |
Betting the Detroit Lions (13-2 SU, 10-5 ATS, 8-7 o/u)
Holding down one of the top spots in the NFC heading into the penultimate week of the NFL season, the Lions have had a historic year. With a first-round bye within their grasp, don’t expect to see the Lions take their foot off the gas in this primetime clash against the 49ers.
Along with their superb regular season record, the Lions have proven that they’re a legitimate powerhouse with their terrific record against the spread. Having covered in 60% of their games played in 2024, with the bulk of those games coming as favourites, the Lions haven’t just been beating teams, they’ve been steamrolling them.
With their eyes set on competing for the elusive Lombardi Trophy, the Lions will have a chance to score some revenge against the team that knocked them out of the NFL playoffs in 2023.
Betting the San Francisco 49ers (6-9 SU, 5-10 ATS, 8-7 o/u)
After opening as favourites to win the Super Bowl in 2024, the 49ers have fallen well short of this mark. Already having been eliminated from playoff contention, this has been a season chock-full of adversity and “what-ifs” in the Bay Area.
With a plethora of injuries across the board, failure to maintain momentum, as well as overall lacklustre play from key contributors on their roster, the 49ers didn’t live up to the hype this season.
Along with their losing record on the season, they’ve been even worse from a betting perspective. Having failed to cover in the majority of their games played, the 49ers currently hold a bottom-five cover rate. Evident by their inability to pull ahead on the scoreboard, the Niners have had next to nothing to be happy about this year.
Key Injuries
Having been one of the most banged-up teams across the NFL this season, the Lions are heading into Monday Night Football with a bill of good health. While LB Jalen Reeves-Maybin and WR Kalif Raymond were moved to the IR this week, no major role players (aside from the previous long-term injuries sustained) on the Lions hold an sort of injury designation this week.
While the Lions appear to be in good standing, the same can’t be said for the 49ers.
Set to be without top cornerback Charvarius Ward against the high-flying Lions offence, the Niners are also expected to be without starting tackles Trent Williams and Cole McKivitz, as well as LB Dre Greenlaw.
Weather
The weather shouldn’t play a factor in the outcome of Monday Night Football. With mild temperatures of 11 C and minimal winds expected, these are ideal playing conditions for January in the NFL.
NFL Betting Trends
- Sporting a 3-0 record in head-to-head play against the NFC West this season, the Lions have scored these victories by an average margin of 8.6 points.
- Having been dominant on the road in 2024, the Lions are 5-1 ATS as road favourites.
- Not used to being the underdog, the 49ers are 0-2 ATS this season when the oddsmakers are against them.
- Continuing to take their lumps within the NFC, the 49ers are 3-7 SU in conference play.
NFL Player Prop Trends
- Having thrown over 1.5 passing touchdowns in four straight starts, Lions quarterback Jared Goff is priced at -200 to extend his scoring streak to five against the Niners.
- With sole control over the Lions backfield, running back Jahmyr Gibbs has had no trouble racking up rushing yards. In Week 17, his line total is set at 93.5 yards, a mark he exceeded in his first matchup as the lone lead back.
- After scoring eight touchdowns in his first nine games played in 2024, 49ers tight end George Kittle has been kept out of the end zone in four consecutive games. Due to end his scoring slump, Kittle is priced at +140.
- Facing a top-five run defence, 49ers running back Isaac Guerendo is set for a tough test on Monday Night Football. With his line set at 64.5 rushing yards, look for him to be kept under wraps this evening.
George Kittle Anytime Touchdown Scorer
Lions vs 49ers Predictions
- Holding more to play for, as well as being the far better team overall, Monday’s matchup should be a cakewalk for the Lions. Facing the shell of the team that bested them in last year’s postseason, the Lions will have no trouble shellacking the 49ers from start to finish in this upcoming tilt. Watch as the Lions continue their take-no-prisoners approach, never letting up, and running up the scoreboard over four quarters as they easily cover the modest 3.5-point spread against the Niners.
- In a matchup sporting multiple scoring threats on both sidelines, bank on points to come early and often on Monday Night Football. Even at a high game total of 50.5 points, the Lions have been no stranger to high-scoring showdowns, often carrying the bulk of the scoring load themselves in their matchups. With a credible dance partner in the 49ers, look for both teams to make trips to the end zone as the over cashes early in this contest.
